… long-term inducible expression up to at least 5 years post gene transfer, with no any detectable
host immune response against the transactivator … recombinant adeno-associated virus …

… A next step in adenoassociated virus-mediated gene therapy for … tetracycline-dependent
transactivator correlates with long-term doxycycline-regulated transgene expression …

… -sensitive doxycycline-inducible adeno-associated virus (AAV) … regulatable system is the
tetracycline-dependent (tet) system. … Since long-term exposure to antibiotics is undesirable, …

… Recombinant AAV vectors have characteristics that make … These observations suggest that
additional long-term dose … such as the tetracycline-controlled transactivator (tTa) and reverse-…

… switch, utilizing a chimeric transactivator designed to evade T cell … long term administration
would have any additional advantage over acute transient delivery. Doxycycline-regulated Tet…

… of diseases characterized by the irreversible loss of light-sensitive … , we generated an
adeno-associated virus vector named … that long-term treatment of RPF2 did not alter retinal …

… can lead to long-term expression in nonhuman primates but in … Many transactivators are
not derived from mammals and … be rejected by the immune system in humans in the long term; …

… of adeno-associated virus (AAV)-delivered transgenes, … transactivator protein for the Tet-On
transcriptional activation … of plasma Epo after the administration of recombinant protein 32,36 …

… Here we used an immune-evasive transactivator generated … short- and sustained long-term
GDNF expression in vivo in … intraspinal adeno-associated viral vector-mediated expression of …

… recombinant Adeno-Associated Viruses (… long term inducible expression up to at least 5
years post-gene transfer with no any detectable host immune response against the transactivator …